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The Science

The discovery and naming of the hormone hepatalin is described in the peer reviewed publication: Canadian Journal of Physiology and Pharmacology.

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Dr. Lautt, Professor Emeritus at the Department of Pharmacology and Therapeutics at the University of Manitoba, has about 220 peer-reviewed publications to his credit. Of these, over 60 are related to HISS (renamed “hepatalin” in 2021), including the following:

  1. Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting
  2. Meal-induced Insulin Sensitization in Conscious and Anesthetized Rat Models Comparing Liquid Mixed Meal with Glucose and Sucrose
  3. Synergistic Protection by S-adenosylmethionine with Vitamins C and E on Liver Injury Induced by Thioacetamide in Rats
  4. HISS-dependent Insulin Resistance (HDIR) in Aged Rats is Associated with Adiposity, Progresses to Syndrome X, and is Attenuated by a Unique Antioxidant Cocktail
  5. Meal-induced Insulin Sensitization (MIS) and its Parasympathetic Regulation in Humans
  6. Bethanechol and N-acetylcysteine Mimic Feeding Signals and Reverse Insulin Resistance in Fasted and Sucrose-induced Diabetic Rats
  7. Absence of meal-induced insulin sensitization (AMIS) in aging rats is associated with cardiac dysfunction that is protected by antioxidants
  8. Lifestyle Impact on Meal-induced Insulin Sensitization in Health and Prediabetes: a Focus on diet, antioxidants, and Exercise Interventions
  9. Obesity as an Early Symptom of the AMIS Syndrome